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표준연, 파킨슨병 등 뇌신경 질환 조기진단·치료 기술 개발

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작성자 관리자 작성일21-11-22 16:07 조회1,016회 댓글8건

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표준연, 파킨슨병 등 뇌신경 질환 


조기진단·치료 기술 개발


도파민 검출할 나노구조 기반 디지털 신호기법 만들어


파킨슨병과 간질 등 뇌신경 질환과 관련한 중요 신경전달물질인 도파민의 농도를 신속·정확히 측정할 수 있는 기술이 개발됐다.

17일 한국표준과학연구원(KRISS)에 따르면 소재융합측정연구소 유은아 책임연구원은 미국 버지니아 공대와 공동연구를 통해 퇴행성 뇌질환이나 알코올·쇼핑·니코틴 등의 다양한 중독증상과 관련된 도파민을 정확하게 검출할 수 있는 디지털 표면증강라만분광(SERS) 센싱 플랫폼을 개발했다.

파킨슨병은 도파민을 분비하는 부분의 신경세포가 손상됐을 때 발생하고, 중독 증상도 뇌에서 도파민 분비량이 과도해지면 충동을 억제하지 못해 나타날 수 있다.

도파민은 대사활동·면역조절과도 관련된 물질이기 때문에 다양한 뇌 신경 관련 질환을 진단하는 데 중요하다.

도파민 수치 변화를 측정하려면 1피코몰(pM, 1조 분의 1몰) 수준까지 정확하게 검출할 수 있는 센서가 필요한데, 전기화학센서는 고감도로 신속하게 검출할 수 있지만 정확성이 떨어진다.

연구팀은 3차원 나노구조 층과 검출대상인 도파민을 선택적으로 인식할 수 있는 금 나노입자를 이용, 도파민이 붙게 되면 강한 신호를 내는 구조를 만들었다.

도파민이 검출됐는지를 하나씩 세는 방식이라서 전체 측정 신호를 합산해 분석하는 기존 기술보다 정확하다.

유은아 책임연구원은 “이번 기술은 실제 사람의 뇌척수액 등의 임상 시료에 바로 적용할 수 있어 응용성이 크다”며 “뇌신경 관련 질환의 조기 진단·치료를 위한 모니터링에 활용할 수 있을 것”이라고 말했다.

이번 연구성과는 나노분야 전문학술지인 나노스케일(Nanoscale, IF:7.790) 11월 표지 논문으로 실렸다.


  •                                          연합뉴스
  •   저작권자  2021.11.19  ⓒ ScienceTimes

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When you are taking it, you'll enhance your body’s capacity to supply pink blood cells, ensuring that your pink blood cell count is maintained and facial hair growth is prevented. There you may have it – every thing you have to learn about Anadrol cycles, dosages, outcomes, and side effects. Be certain to do your analysis and consult with a certified medical skilled before starting any cycle. Extended use can increase the risk of liver harm and different well being problems. https://www.valley.md/buy-winstrol

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